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Key advances in optical manipulation for biophotonics

Key advances in optical manipulation for biophotonics

Our direct force spectroscopy technology considered to be among the main key advances in optical manipulation for biophotonics.

The IMPETUX’s exclusive technology to measure forces inside living cells and tissues has been considered one of the key advances in the field of optical manipulation of the last decade in the recent review by Dr. Stella Corsetti and Prof. Kishan Dholakia:

“Optical manipulation: advances for biophotonics in the 21st century”

J. of Biomedical Optics, 26(7), 070602 (2021). https://doi.org/10.1117/1.JBO.26.7.070602

 

We cannot be more proud and honored to see that our work is recognized among the best experts in the field and we are thrilled to contribute in the expansion of the optical manipulation capabilities with such an important advance for quantitative force measurement in biological systems.

You can read the publication here.

 

📌 You can also check the multiple advantages of our distinctive direct force spectroscopy technology here. SENSOCELL is the only system in the market integrating this technology. Have a look at this and other extraordinary features of our SENSOCELL optical tweezers platform here.

We are providing a technology that is currently allowing to deepen our understanding of fundamental biological processes and that is exciting! Want to know more? contact us!.

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Fig. 1

Time dependence of trap position (top), force signal (middle) and Ca2+ fluorescence signal (bottom) recorded during a membrane tether pulling experiment. The force and Ca2+ ion channel activity signals exhibit negative correlation.

Fig. 2

Force and displacement data for two beads stimulated at frequencies of 4 Hz and 0.25 Hz. The progressive reduction of the beads displacement is in concomitancy with an increase of the applied force and loading rate.

Fig. 1

Schematic representation of the optical tweezers experiment. A fibronectin-coated bead is trapped, brought into contact with the cell membrane and stimulated with oscillations at different frequencies.

Fig.2

Time dependence of trap 1 and trap 2 position (top) and force (bottom) data along the different steps of the described dual tether pulling experiment.

Fig.1

Confocal video of the described dual tether pulling assay performed on a neuron axon. Courtesy of M. Krieg lab (ICFO).

Fig. 1

Time dependence of trap position (top), force signal (middle) and Ca2+ fluorescence signal (bottom) recorded during a membrane tether pulling experiment. The force and Ca2+ ion channel activity signals exhibit negative correlation.

Video 1

Confocal video showing a DVA neuron Ca2+ ion channel activity in a dynamic optical trapping assay. The pulling rate applied to the membrane tether is progressively increased. Scale bar = 5µm. Acquired at 10Hz.